White matter atrophy can be caused by many circumstances including chronic hypertension as well as old age. Vascular encephalopathy of the brain in the stage of decompensation manifested by speech decreased swallowing reflex there is tremor of the limbs and discoordination. Encephalopathy may be caused by infectious agent bacteria virus or prion metabolic or mitochondrial dysfunction brain tumor or increased pressure in the skull prolonged exposure to toxic elements including solvents drugs radiation paints industrial chemicals and certain metals chronic progressive trauma poor nutrition or lack of oxygen or blood flow to the brain.
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